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Paroxysmal Nocturnal Hemoglobinuria: Translating Pathobiology Into Modern Clinical Management

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Listen to expert hematologists provide an up-to-date clinical overview of paroxysmal nocturnal hemoglobinuria (PNH), exploring its pathogenesis, clinical manifestations, and the evolution of complement-based therapies.

Released: October 28, 2025

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Provided by Clinical Care Options, LLC

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Supported by an educational grant from Novartis Pharmaceuticals Corporation.

Novartis Pharmaceuticals Corporation

Faculty Disclosure

Primary Author

Carlos M. De Castro, MD: consultant/advisor/speaker: Alexion/AstraZeneca, Apellis, BioCryst, Genentech, Novartis, Omeros; data and safety monitoring board: Regeneron.

David Dingli, MD, PhD, FRCP, FRCPEd, FACP, FRCPath: consultant/advisor/speaker: Alexion, Bristol Myers Squibb, Johnson & Johnson, Merck Sharp & Dohme, Novartis, Regeneron.