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What All Practitioners Should Know About Mechanisms and Assessment of Pain


This 1.5-hour webcast is an on-demand version of the live webinar held in October 2022. Experts Ameet Nagpal, MD, MS, MEd, MBA and Amanda Zimmerman, PA-C, provide valuable information about mechanisms of pain, appropriate assessment of pain, and strategies for risk assessment for abuse, misuse, and opioid use disorder.

Physician Assistants/Physician Associates: 1.50 AAPA Category 1 CME credits

Nurses: 1.50 Nursing contact hours

Physicians: maximum of 1.50 AMA PRA Category 1 Credits

Social Workers: 1.50 ASWB ACE CE Credits

Pharmacists: 1.50 contact hours (0.15 CEUs)

Released: January 10, 2023

Expiration: January 09, 2024

No longer available for credit.



Ameet Nagpal

Ameet Nagpal, MD, MS, MEd, MBA

Professor, Department of Orthopedics & Physical Medicine
Division Chief, Physical Medicine & Rehabilitation
Medical University of South Carolina College of Medicine
Charleston, South Carolina

Amanda Zimmerman

Amanda Zimmerman, PA-C

West Forsyth Pain Management
Winston Salem, North Carolina

Provided by

Provided by Clinical Care Options, LLC, and in partnership with the American Academy of Physical Medicine and Rehabilitation, Alliance to Advance Comprehensive Integrative Pain Management, Practicing Clinicians Exchange, and ProCE.

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This activity is supported by an independent educational grant from the Opioid Analgesic REMS Program Companies. Please see this link for a listing of REMS Program Companies. This activity is intended to be fully compliant with the Opioid Analgesic REMS education requirements issued by the FDA.

Opioid Analgesic REMS Program Companies


Alliance to Advance Comprehensive Integrative Pain Management

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American Academy of Physical Medicine and Rehabilitation

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Practicing Clinicians Exchange

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Target Audience

The Opioid REMS Microlearning Initiative is intended to reach the entire healthcare team including physicians, advanced practice nurses, physician associates/physician assistants, pharmacists, nurses, psychologists, and social workers. Specialty areas include, but are not limited to, physiatry, psychiatry, neurology, family medicine, internal medicine, oncology, pain management, and surgery. This includes HCPs who are involved with direct patient care, including HCPs registered with the DEA and eligible to prescribe all opioid analgesics, as well as non-prescribers involved in the care of patients receiving opioid analgesic therapy, nonpharmacologic therapies, and nonopioid analgesic therapies.

Program Learning Goal

The goal of this program is to optimize learners' translation of pain management knowledge into practice, including the role and risks of opioids and strategies to minimize adverse outcomes of opioid use.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify fundamental concepts of pain management, including mechanisms of pain; risk factors for misuse, abuse and opioid use disorder; and appropriate assessment of pain


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Ameet Nagpal, MD, MS, MEd, MBA

Professor, Department of Orthopedics & Physical Medicine
Division Chief, Physical Medicine & Rehabilitation
Medical University of South Carolina College of Medicine
Charleston, South Carolina

Ameet Nagpal, MD, MS, MEd, MBA: consultant/advisor/speaker: Averitas.

Amanda Zimmerman, PA-C

West Forsyth Pain Management
Winston Salem, North Carolina

The planners and content peer reviewers from Clinical Care Options, LLC, the American Academy of Physical Medicine and Rehabilitation (AAPMR), Alliance to Advance Comprehensive Integrative Pain Management, Practicing Clinicians Exchange, and ProCE, do not have any relevant financial relationships to disclose, except Gabrielle Giacona as noted below:

Gabrielle Giacona: stock/stock options: AstraZeneca, Moderna.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.5 hours. To successfully complete this activity and receive credit, learners must follow these steps during the period from January 10, 2023, through January 09, 2024:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Learners have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by healthcare professionals without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physician Continuing Medical Education
CCO designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 1.5 contact hours.

Continuing Pharmacy Education

CCO designates this continuing education activity for 1.5 contact hours (0.15 CEUs) of the Accreditation Council for Pharmacy Education.

UAN: JA4008176-0000-22-186-H08-P
Type of Activity: Application

Upon successfully completing the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.

Physician Assistant/Physician Associate Continuing  Medical Education

Joint AccreditationClinical Care Options, LLC has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.5 AAPA Category 1 CME credits. Approval is valid until January 09, 2024. PAs should only claim commensurate with the extent of their participation.

Psychologist Continuing Education

Continuing education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs.
This activity offers 1.5 continuing education credits for psychologists.

Social Work Continuing Education 

As a Jointly Accredited Organization, Clinical Care Options, LLC is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this course receive 1.5 clinical continuing education credits.